A novel Hsp90 inhibitor AT13387 induces senescence in EBV-positive nasopharyngeal carcinoma cells and suppresses tumor formation

BACKGROUND: Nasopharyngeal carcinoma (NPC) is an epithelial malignancy strongly associated with Epstein-Barr virus (EBV). AT13387 is a novel heat shock protein 90 (Hsp90) inhibitor, which inhibits the chaperone function of Hsp90 and reduces expression of Hsp90-dependent client oncoproteins. This stu...

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Hlavní autoři: Chan, King Chi, Ting, Choi Man, Chan, Pui Shan, Lo, Ming Chu, Lo, Kwok Wai, Curry, Jayne E, Smyth, Tomoko, Lee, Anne Wing Mui, Ng, Wai Tong, Tsao, George Sai Wah, Wong, Ricky Ngok Shun, Lung, Maria Li, Mak, Nai Ki
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2013
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Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834878/
https://ncbi.nlm.nih.gov/pubmed/24156782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-12-128
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