An Extensive Network of TET2-Targeting microRNAs Regulates Malignant Hematopoiesis

The Ten-Eleven-Translocation 2 (TET2) gene, which oxidates 5-methylcytosine in DNA to 5-hydroxylmethylcytosine (5hmC), is a key tumor suppressor frequently mutated in hematopoietic malignancies. However, the molecular regulation of TET2 expression is poorly understood. We show that TET2 is under ext...

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Huvudupphovsmän: Cheng, Jijun, Guo, Shangqin, Chen, Suning, Mastriano, Stephen J., Liu, Chaochun, D’Alessio, Ana C., Hysolli, Eriona, Guo, Yanwen, Yao, Hong, Megyola, Cynthia M., Li, Dan, Liu, Jun, Pan, Wen, Roden, Christine A., Zhou, Xiao-Ling, Heydari, Kartoosh, Chen, Jianjun, Park, In-Hyun, Ding, Ye, Zhang, Yi, Lu, Jun
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2013
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834864/
https://ncbi.nlm.nih.gov/pubmed/24120864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.08.050
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