BRD4 Short Isoform Interacts with RRP1B, SIPA1 and Components of the LINC Complex at the Inner Face of the Nuclear Membrane

Recent studies suggest that BET inhibitors are effective anti-cancer therapeutics. Here we show that BET inhibitors are effective against murine primary mammary tumors, but not pulmonary metastases. BRD4, a target of BET inhibitors, encodes two isoforms with opposite effects on tumor progression. To...

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Bibliografski detalji
Glavni autori: Alsarraj, Jude, Faraji, Farhoud, Geiger, Thomas R., Mattaini, Katherine R., Williams, Mia, Wu, Josephine, Ha, Ngoc-Han, Merlino, Tyler, Walker, Renard C., Bosley, Allen D., Xiao, Zhen, Andresson, Thorkell, Esposito, Dominic, Smithers, Nicholas, Lugo, Dave, Prinjha, Rab, Day, Anup, Crawford, Nigel P. S., Ozato, Keiko, Gardner, Kevin, Hunter, Kent W.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834312/
https://ncbi.nlm.nih.gov/pubmed/24260471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080746
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