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High Resolution Crystal Structure of Human β-Glucuronidase Reveals Structural Basis of Lysosome Targeting
Human β-glucuronidase (GUS) cleaves β-D-glucuronic acid residues from the non-reducing termini of glycosaminoglycan and its deficiency leads to mucopolysaccharidosis type VII (MPSVII). Here we report a high resolution crystal structure of human GUS at 1.7 Å resolution and present an extensive analys...
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| Главные авторы: | , , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science
2013
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3834196/ https://ncbi.nlm.nih.gov/pubmed/24260279 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079687 |
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