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Targeted Precise Quantification of 12 Human Recombinant Uridine-Diphosphate Glucuronosyl Transferase 1A and 2B Isoforms Using Nano-Ultra-High-Performance Liquid Chromatography/Tandem Mass Spectrometry with Selected Reaction Monitoring

Quantification methods employing stable isotope-labeled peptide standards and liquid chromatography–tandem mass spectrometry are increasingly being used to measure enzyme amounts in biologic samples. Isoform concentrations, combined with catalytic information, can be used in absorption, distribution...

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Detalhes bibliográficos
Main Authors: Fallon, John K., Neubert, Hendrik, Goosen, Theunis C., Smith, Philip C.
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3834135/
https://ncbi.nlm.nih.gov/pubmed/24046331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.113.053801
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