A self-limiting switch based on translational control regulates the transition from proliferation to differentiation in an adult stem cell lineage

In adult stem cell lineages, progenitor cells commonly undergo mitotic transit amplifying (TA) divisions before terminal differentiation, allowing production of many differentiated progeny per stem cell division. Mechanisms that limit TA divisions and trigger the switch to differentiation may protec...

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Autori principali: Insco, Megan L., Bailey, Alexis S., Kim, Jongmin, Olivares, Gonzalo H., Wapinski, Orly L., Tam, Cheuk Ho, Fuller, Margaret T.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833810/
https://ncbi.nlm.nih.gov/pubmed/23122292
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2012.08.012
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