Interleukin-1 promotion of MAPK-p38 overexpression in experimental animals and in Alzheimer’s disease: potential significance for tau protein phosphorylation

Activated (phosphorylated) mitogen-activated protein kinase p38 (MAPK-p38) and interleukin-1 (IL-1) have both been implicated in the hyperphosphorylation of tau, a major component of the neurofibrillary tangles in Alzheimer’s disease. This, together with findings showing that IL-1 activates MAPK-p38...

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Main Authors: Sheng, Jin G., Jones, Richard A., Zhou, Xue Q., McGinness, John M., Van Eldik, Linda J., Mrak, Robert E., Griffin, W. Sue T.
Format: Artigo
Jezik:Inglês
Izdano: 2001
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3833633/
https://ncbi.nlm.nih.gov/pubmed/11578769
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