A Cell-Free Fluorometric High-Throughput Screen for Inhibitors of Rtt109-Catalyzed Histone Acetylation

The lysine acetyltransferase (KAT) Rtt109 forms a complex with Vps75 and catalyzes the acetylation of histone H3 lysine 56 (H3K56ac) in the Asf1-H3-H4 complex. Rtt109 and H3K56ac are vital for replication-coupled nucleosome assembly and genotoxic resistance in yeast and pathogenic fungal species suc...

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Main Authors: Dahlin, Jayme L., Sinville, Rondedrick, Solberg, Jonathan, Zhou, Hui, Han, Junhong, Francis, Subhashree, Strasser, Jessica M., John, Kristen, Hook, Derek J., Walters, Michael A., Zhang, Zhiguo
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2013
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832525/
https://ncbi.nlm.nih.gov/pubmed/24260132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078877
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