Response of Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Xenografts to a Survivin Inhibitor

Merkel cell carcinoma (MCC) is a neuroendocrine skin cancer associated with high mortality. Merkel cell polyomavirus (MCV), discovered in 2008, is associated with ~80% of MCC. The MCV large tumor (LT) oncoprotein upregulates the cellular oncoprotein survivin through its conserved retinoblastoma prot...

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Bibliographic Details
Main Authors: Dresang, Lindsay R., Guastafierro, Anna, Arora, Reety, Normolle, Daniel, Chang, Yuan, Moore, Patrick S.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832378/
https://ncbi.nlm.nih.gov/pubmed/24260412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080543
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