Pesticides that Inhibit the Ubiquitin-Proteasome System: Effect Measure Modification by Genetic Variation in SKP1 in Parkinson’s Disease

Cytoplasmic inclusions known as Lewy bodies, a hallmark of Parkinson’s disease (PD) pathology, may protect against cytotoxic proteins. Since the ubiquitin-proteasome system (UPS) degrades cytotoxic proteins, dysfunction in the UPS may contribute to PD etiology. Our goal in this study was to screen p...

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Autori principali: Rhodes, Shannon L., Fitzmaurice, Arthur G., Cockburn, Myles, Bronstein, Jeff M., Sinsheimer, Janet S., Ritz, Beate
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832349/
https://ncbi.nlm.nih.gov/pubmed/23988235
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.envres.2013.08.001
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