A Novel Intronic Single Nucleotide Polymorphism in the Myosin heavy polypeptide 4 Gene Is Responsible for the Mini-Muscle Phenotype Characterized by Major Reduction in Hind-Limb Muscle Mass in Mice

Replicated artificial selection for high levels of voluntary wheel running in an outbred strain of mice favored an autosomal recessive allele whose primary phenotypic effect is a 50% reduction in hind-limb muscle mass. Within the High Runner (HR) lines of mice, the numerous pleiotropic effects (e.g....

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Auteurs principaux: Kelly, Scott A., Bell, Timothy A., Selitsky, Sara R., Buus, Ryan J., Hua, Kunjie, Weinstock, George M., Garland, Theodore, Pardo-Manuel de Villena, Fernando, Pomp, Daniel
Format: Artigo
Langue:Inglês
Publié: Genetics Society of America 2013
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Investigations
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832280/
https://ncbi.nlm.nih.gov/pubmed/24056412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.154476
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