A Novel Intronic Single Nucleotide Polymorphism in the Myosin heavy polypeptide 4 Gene Is Responsible for the Mini-Muscle Phenotype Characterized by Major Reduction in Hind-Limb Muscle Mass in Mice

Replicated artificial selection for high levels of voluntary wheel running in an outbred strain of mice favored an autosomal recessive allele whose primary phenotypic effect is a 50% reduction in hind-limb muscle mass. Within the High Runner (HR) lines of mice, the numerous pleiotropic effects (e.g....

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Autores principales: Kelly, Scott A., Bell, Timothy A., Selitsky, Sara R., Buus, Ryan J., Hua, Kunjie, Weinstock, George M., Garland, Theodore, Pardo-Manuel de Villena, Fernando, Pomp, Daniel
Formato: Artigo
Lenguaje:Inglês
Publicado: Genetics Society of America 2013
Materias:
Investigations
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3832280/
https://ncbi.nlm.nih.gov/pubmed/24056412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.113.154476
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