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Formation of 5-hydroxykynurenine and 5-hydroxykynurenamine from 5-hydroxytryptophan in rabbit small intestine

In order to clarify the role of indoleamine 2,3-dioxygenase [indole:oxygen 2,3-oxidoreductase (decyclizing), EC 1.13.11.17] in the metabolism of serotonin, DL-5-hydroxy[methylene-(14)C]tryptophan, a precursor of serotonin, was incubated with slices of rabbit ileum. Resulting metabolites were separat...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Fujiwara, Motokazu, Shibata, Masakatsu, Nomiyama, Yoshitsugu, Sugimoto, Tetsuo, Hirata, Fusao, Tokuyama, Takashi, Senoh, Siro, Hayaishi, Osamu
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1979
Fag:
Biological Sciences: Biochemistry
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383206/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/312499/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.3.1145
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