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Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes

Sequential production of body segments in vertebrate embryos is regulated by a molecular oscillator (the segmentation clock) that drives cyclic transcription of genes involved in positioning intersegmental boundaries. Mathematical modeling indicates that the period of the clock depends on the total...

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Main Authors: Hoyle, Nathaniel P., Ish-Horowicz, David
格式: Artigo
語言:Inglês
出版: National Academy of Sciences 2013
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831944/
https://ncbi.nlm.nih.gov/pubmed/24151332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1308811110
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