Indoles mitigate the development of experimental autoimmune encephalomyelitis by induction of reciprocal differentiation of regulatory T cells and Th17 cells

BACKGROUND AND PURPOSE: Dietary indole derivatives, indole-3-carbinol (I3C) and diindolylmethane (DIM), possess anti-cancer properties and exhibit the characteristics of aryl hydrocarbon receptor (AhR) ligands. Because AhR activation has recently been shown to regulate T cell differentiation, we tes...

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Библиографические подробности
Главные авторы: Rouse, Michael, Singh, Narendra P, Nagarkatti, Prakash S, Nagarkatti, Mitzi
Формат: Artigo
Язык:Inglês
Опубликовано: Blackwell Publishing Ltd 2013
Предметы:
Research Papers
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831710/
https://ncbi.nlm.nih.gov/pubmed/23586923
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.12205
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