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Nitrite produced by Mycobacterium tuberculosis in human macrophages in physiologic oxygen impacts bacterial ATP consumption and gene expression

In high enough concentrations, such as produced by inducible nitric oxide synthase (iNOS), reactive nitrogen species (RNS) can kill Mycobacterium tuberculosis (Mtb). Lesional macrophages in macaques and humans with tuberculosis express iNOS, and mice need iNOS to avoid succumbing rapidly to tubercul...

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Sonraí Bibleagrafaíochta
Main Authors: Cunningham-Bussel, Amy, Zhang, Tuo, Nathan, Carl F.
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2013
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3831502/
https://ncbi.nlm.nih.gov/pubmed/24145454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1316894110
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