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Genetically Modified Bacterial Strains and Novel Bacterial Artificial Chromosome Shuttle Vectors for Constructing Environmental Libraries and Detecting Heterologous Natural Products in Multiple Expression Hosts

The enormous diversity of uncultured microorganisms in soil and other environments provides a potentially rich source of novel natural products, which is critically important for drug discovery efforts. Our investigators reported previously on the creation and screening of an Escherichia coli librar...

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Detalhes bibliográficos
Main Authors: Martinez, Asuncion, Kolvek, Steven J., Tiong Yip, Choi Lai, Hopke, Joern, Brown, Kara A., MacNeil, Ian A., Osburne, Marcia S.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC383137/
https://ncbi.nlm.nih.gov/pubmed/15066844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.70.4.2452-2463.2004
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