Changes in quaternary structure of IgG upon reduction of the interheavy-chain disulfide bond.
Reduction of the single disulfide bond between heavy chains in the hinge region of rabbit IgG antibody causes destabilization of the CH2 region of the molecule. Our studies indicate that reduced antibody molecules undergo a large change in quaternary structure in the CH2 region upon aggregation with...
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| Udgivet i: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1979
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC383089/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/106398/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.76.2.907 |
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