Phosphodiesterase 5 Attenuates the Vasodilatory Response in Renovascular Hypertension

NO/cGMP signaling plays an important role in vascular relaxation and regulation of blood pressure. The key enzyme in the cascade, the NO-stimulated cGMP-forming guanylyl cyclase exists in two enzymatically indistinguishable isoforms (NO-GC1, NO-GC2) with NO-GC1 being the major NO-GC in the vasculatu...

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Hlavní autoři: Stegbauer, Johannes, Friedrich, Sebastian, Potthoff, Sebastian A., Broekmans, Kathrin, Cortese-Krott, Miriam M., Quack, Ivo, Rump, Lars Christian, Koesling, Doris, Mergia, Evanthia
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829872/
https://ncbi.nlm.nih.gov/pubmed/24260450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0080674
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