An Optical Probe for Noninvasive Molecular Imaging of Orthotopic Brain Tumors Overexpressing Epidermal Growth Factor Receptor

We have developed a near-infrared (NIR) probe that targets cells overexpressing the EGF receptor (EGFR) for imaging glioblastoma brain tumors in live subjects. A peptide specific for the EGFR was modified with various lengths of monodiscrete polyethylene glycol (PEG) units and a NIR Cy5.5 fluorescen...

Full description

Saved in:
Bibliographic Details
Main Authors: Agnes, Richard S., Broome, Ann-Marie, Wang, Jing, Verma, Anjali, Lavik, Kari, Basilion, James P.
Format: Artigo
Language:Inglês
Published: 2012
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829608/
https://ncbi.nlm.nih.gov/pubmed/22807580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-0211
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items