Disarming Bacterial Virulence through Chemical Inhibition of the DNA Binding Domain of an AraC-like Transcriptional Activator Protein

The misuse of antibiotics during past decades has led to pervasive antibiotic resistance in bacteria. Hence, there is an urgent need for the development of new and alternative approaches to combat bacterial infections. In most bacterial pathogens the expression of virulence is tightly regulated at t...

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Detalhes bibliográficos
Main Authors: Yang, Ji, Hocking, Dianna M., Cheng, Catherine, Dogovski, Con, Perugini, Matthew A., Holien, Jessica K., Parker, Michael W., Hartland, Elizabeth L., Tauschek, Marija, Robins-Browne, Roy M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829424/
https://ncbi.nlm.nih.gov/pubmed/24019519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503912
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