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Disarming Bacterial Virulence through Chemical Inhibition of the DNA Binding Domain of an AraC-like Transcriptional Activator Protein

The misuse of antibiotics during past decades has led to pervasive antibiotic resistance in bacteria. Hence, there is an urgent need for the development of new and alternative approaches to combat bacterial infections. In most bacterial pathogens the expression of virulence is tightly regulated at t...

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Autors principals: Yang, Ji, Hocking, Dianna M., Cheng, Catherine, Dogovski, Con, Perugini, Matthew A., Holien, Jessica K., Parker, Michael W., Hartland, Elizabeth L., Tauschek, Marija, Robins-Browne, Roy M.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829424/
https://ncbi.nlm.nih.gov/pubmed/24019519
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.503912
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