A Crystal Structure of the Dengue Virus Non-structural Protein 5 (NS5) Polymerase Delineates Interdomain Amino Acid Residues That Enhance Its Thermostability and de Novo Initiation Activities

The dengue virus (DENV) non-structural protein 5 (NS5) comprises an N-terminal methyltransferase and a C-terminal RNA-dependent RNA polymerase (RdRp) domain. Both enzymatic activities form attractive targets for antiviral development. Available crystal structures of NS5 fragments indicate that resid...

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Detalhes bibliográficos
Main Authors: Lim, Siew Pheng, Koh, Jolene Hong Kiew, Seh, Cheah Chen, Liew, Chong Wai, Davidson, Andrew D., Chua, Leng Shiew, Chandrasekaran, Ramya, Cornvik, Tobias C., Shi, Pei-Yong, Lescar, Julien
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829423/
https://ncbi.nlm.nih.gov/pubmed/24025331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.508606
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