Jun Activation Domain-binding Protein 1 (JAB1) Is Required for the Optimal Response to Interferons

Degradation of IFN receptor (IFNR) protein is one of the mechanisms to limit the extent of cellular responses to interferons. Tyrosine kinase 2 (TYK2), a JAK family kinase, has been reported to bind to and stabilize IFNR, indicating that TYK2 is a fundamental component of IFNR complex. Herein, we id...

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Main Authors: Muromoto, Ryuta, Nakajima, Maiko, Hirashima, Koki, Hirao, Toru, Kon, Shigeyuki, Shimoda, Kazuya, Oritani, Kenji, Matsuda, Tadashi
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Protein Synthesis and Degradation
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829410/
https://ncbi.nlm.nih.gov/pubmed/24043623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.485847
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