UV-triggered Affinity Capture Identifies Interactions between the Plasmodium falciparum Multidrug Resistance Protein 1 (PfMDR1) and Antimalarial Agents in Live Parasitized Cells

A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reactive affinity capture method to find parasite proteins specifically interacting with the capture com...

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Autores principales: Brunner, Ralf, Ng, Caroline L., Aissaoui, Hamed, Akabas, Myles H., Boss, Christoph, Brun, Reto, Callaghan, Paul S., Corminboeuf, Olivier, Fidock, David A., Frame, Ithiel J., Heidmann, Bibia, Le Bihan, Amélie, Jenö, Paul, Mattheis, Corinna, Moes, Suzette, Müller, Ingrid B., Paguio, Michelle, Roepe, Paul D., Siegrist, Romain, Voss, Till, Welford, Richard W. D., Wittlin, Sergio, Binkert, Christoph
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2013
Materias:
Molecular Bases of Disease
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829344/
https://ncbi.nlm.nih.gov/pubmed/23754276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.453159
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