The Ras GTPase-activating-like Protein IQGAP1 Mediates Nrf2 Protein Activation via the Mitogen-activated Protein Kinase/Extracellular Signal-regulated Kinase (ERK) Kinase (MEK)-ERK Pathway

Nrf2 plays a critical role in the regulation of cellular oxidative stress. MEK-ERK activation has been shown to be one of the major pathways resulting in the activation of Nrf2 and induction of Nrf2 downstream targets, including phase II detoxifying/antioxidant genes in response to oxidative stress...

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Bibliographische Detailangaben
Hauptverfasser: Cheung, Ka Lung, Lee, Jong Hun, Shu, Limin, Kim, Jung-Hwan, Sacks, David B., Kong, Ah-Ng Tony
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2013
Schlagworte:
Gene Regulation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829328/
https://ncbi.nlm.nih.gov/pubmed/23788642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444182
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