A TRPC1 Protein-dependent Pathway Regulates Osteoclast Formation and Function

Ca(2+) signaling is essential for bone homeostasis and skeletal development. Here, we show that the transient receptor potential canonical 1 (TRPC1) channel and the inhibitor of MyoD family, I-mfa, function antagonistically in the regulation of osteoclastogenesis. I-mfa null mice have an osteopenic...

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Detalhes bibliográficos
Main Authors: Ong, E-Ching, Nesin, Vasyl, Long, Courtney L., Bai, Chang-Xi, Guz, Jan L., Ivanov, Ivaylo P., Abramowitz, Joel, Birnbaumer, Lutz, Humphrey, Mary Beth, Tsiokas, Leonidas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3829314/
https://ncbi.nlm.nih.gov/pubmed/23770672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.459826
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