Loss of Apelin Exacerbates Myocardial Infarction Adverse Remodeling and Ischemia‐reperfusion Injury: Therapeutic Potential of Synthetic Apelin Analogues

BACKGROUND: Coronary artery disease leading to myocardial ischemia is the most common cause of heart failure. Apelin (APLN), the endogenous peptide ligand of the APJ receptor, has emerged as a novel regulator of the cardiovascular system. METHODS AND RESULTS: Here we show a critical role of APLN in...

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Bibliographic Details
Main Authors: Wang, Wang, McKinnie, Shaun M.K., Patel, Vaibhav B., Haddad, George, Wang, Zuocheng, Zhabyeyev, Pavel, Das, Subhash K., Basu, Ratnadeep, McLean, Brent, Kandalam, Vijay, Penninger, Josef M., Kassiri, Zamaneh, Vederas, John C., Murray, Allan G., Oudit, Gavin Y.
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2013
Subjects:
Original Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828798/
https://ncbi.nlm.nih.gov/pubmed/23817469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.113.000249
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