Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule.

Graves disease is an autoimmune thyroid disease characterized by the presence of antibodies against the thyrotropin receptor (TSHR), which stimulate the thyroid to cause hyperthyroidism and/or goiter. By immunizing mice with fibroblasts transfected with both the human TSHR and a major histocompatibi...

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Detalhes bibliográficos
Main Authors: Shimojo, N, Kohno, Y, Yamaguchi, K, Kikuoka, S, Hoshioka, A, Niimi, H, Hirai, A, Tamura, Y, Saito, Y, Kohn, L D, Tahara, K
Formato: Artigo
Idioma:Inglês
Publicado em: 1996
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC38286/
https://ncbi.nlm.nih.gov/pubmed/8855311
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