Induction of Graves-like disease in mice by immunization with fibroblasts transfected with the thyrotropin receptor and a class II molecule.

Graves disease is an autoimmune thyroid disease characterized by the presence of antibodies against the thyrotropin receptor (TSHR), which stimulate the thyroid to cause hyperthyroidism and/or goiter. By immunizing mice with fibroblasts transfected with both the human TSHR and a major histocompatibi...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Shimojo, N, Kohno, Y, Yamaguchi, K, Kikuoka, S, Hoshioka, A, Niimi, H, Hirai, A, Tamura, Y, Saito, Y, Kohn, L D, Tahara, K
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1996
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC38286/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8855311/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.93.20.11074
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