Germinal Center Centroblasts Transition to a Centrocyte Phenotype According to a Timed Program and Depend on the Dark Zone for Effective Selection

Germinal center (GC) B cells cycle between the dark zone (DZ) and light zone (LZ) during antibody affinity maturation. Whether this movement is necessary for GC function has not been tested. Here we show that CXCR4-deficient GC B cells, which are restricted to the LZ, are gradually outcompeted by WT...

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Main Authors: Bannard, Oliver, Horton, Robert M., Allen, Christopher D.C., An, Jinping, Nagasawa, Takashi, Cyster, Jason G.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828484/
https://ncbi.nlm.nih.gov/pubmed/24184055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.08.038
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