Intracellular Interferons in Fish: A Unique Means to Combat Viral Infection

We demonstrate for the first time in vertebrates, that alternative splicing of interferon (IFN) genes can lead to a functional intracellular IFN (iIFN). Fish IFN genes possess introns and in rainbow trout three alternatively spliced transcripts of the IFN1 gene exist. Two of the encoded IFNs are pre...

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Bibliografiske detaljer
Main Authors: Chang, Ming-Xian, Zou, Jun, Nie, Pin, Huang, Bei, Yu, Zhanglong, Collet, Bertrand, Secombes, Chris J.
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828176/
https://ncbi.nlm.nih.gov/pubmed/24244163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003736
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