Pharmacometric Analyses to Support Early Development Decisions for LY2878735: A Novel Serotonin Norepinephrine Reuptake Inhibitor

LY2878735 is a novel dual serotonin (5-hydroxytryptamine (5-HT)) and norepinephrine (NE) reuptake inhibitor (SNRI) in development for chronic pain indications. In vitro profile suggests a more balanced profile as compared with other SNRI's, which is expected to confer superior clinical efficacy...

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Bibliographische Detailangaben
Hauptverfasser: Raddad, E, Melhem, M R, Sloan-Lancaster, J S, Miller, J W, Van Wart, S A, Rubino, C M
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3828007/
https://ncbi.nlm.nih.gov/pubmed/23965782
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/psp.2013.43
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