Zebularine inhibits tumorigenesis and stemness of colorectal cancer via p53-dependent endoplasmic reticulum stress

Aberrant DNA hypermethylation is frequently found in tumor cells and inhibition of DNA methylation is an effective anticancer strategy. In this study, the therapeutic effect of DNA methyltransferase (DNMT) inhibitor zebularine (Zeb) on colorectal cancer (CRC) was investigated. Zeb exhibited anticanc...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Pei-Ming, Lin, Yi-Ting, Shun, Chia-Tung, Lin, Shan-Hu, Wei, Tzu-Tang, Chuang, Shu-Hui, Wu, Ming-Shiang, Chen, Ching-Chow
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827606/
https://ncbi.nlm.nih.gov/pubmed/24225777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03219
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