к Opioids inhibit tumor angiogenesis by suppressing VEGF signaling

Opioids are effective analgesics for the management of moderate to severe cancer pain. Here we show that κ opioid receptor (KOR) agonists act as anti-angiogenic factors in tumors. Treatment with KOR agonists, U50,488H and TRK820, significantly inhibited human umbilical vein endothelial cell (HUVEC)...

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Detalhes bibliográficos
Main Authors: Yamamizu, Kohei, Furuta, Sadayoshi, Hamada, Yusuke, Yamashita, Akira, Kuzumaki, Naoko, Narita, Michiko, Doi, Kento, Katayama, Shiori, Nagase, Hiroshi, Yamashita, Jun K., Narita, Minoru
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827603/
https://ncbi.nlm.nih.gov/pubmed/24225480
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep03213
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