Prophylactic efficacy and pharmacokinetically guided dosing of a von Willebrand factor/factor VIII concentrate in adults and children with von Willebrand's disease undergoing elective surgery: a pooled and comparative analysis of data from USA and European Union clinical trials

BACKGROUND: Surgical intervention may pose significant risk of life-threatening bleeding in patients with von Willebrand's disease; prophylactic treatment with von Willebrand factor/factor VIII concentrate is generally indicated for von Willebrand's disease characterized by moderate to sev...

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Detalhes bibliográficos
Main Authors: Mannucci, Pier Mannuccio, Kyrle, Paul Alexander, Schulman, Sam, Di Paola, Jorge, Schneppenheim, Reinhard, Gill, Joan Cox
Formato: Artigo
Idioma:Inglês
Publicado em: Edizioni SIMTI - SIMTI Servizi Srl 2013
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3827397/
https://ncbi.nlm.nih.gov/pubmed/23736911
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2450/2013.0254-12
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