A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders

Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones. UDP-glucuronosyltransferases (UGTs) are involved in the conjugation and elimination of many xenobiotics and endogeno...

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Hlavní autoři: Fang, Zhong-Ze, He, Rong-Rong, Cao, Yun-Feng, Tanaka, Naoki, Jiang, Changtao, Krausz, Kristopher W., Qi, Yunpeng, Dong, Pei-Pei, Ai, Chun-Zhi, Sun, Xiao-Yu, Hong, Mo, Ge, Guang-Bo, Gonzalez, Frank J., Ma, Xiao-Chi, Sun, Hong-Zhi
Médium: Artigo
Jazyk:Inglês
Vydáno: The American Society for Biochemistry and Molecular Biology 2013
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Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826681/
https://ncbi.nlm.nih.gov/pubmed/24115227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M040519
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