A model of in vitro UDP-glucuronosyltransferase inhibition by bile acids predicts possible metabolic disorders

Increased levels of bile acids (BAs) due to the various hepatic diseases could interfere with the metabolism of xenobiotics, such as drugs, and endobiotics including steroid hormones. UDP-glucuronosyltransferases (UGTs) are involved in the conjugation and elimination of many xenobiotics and endogeno...

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Detalhes bibliográficos
Main Authors: Fang, Zhong-Ze, He, Rong-Rong, Cao, Yun-Feng, Tanaka, Naoki, Jiang, Changtao, Krausz, Kristopher W., Qi, Yunpeng, Dong, Pei-Pei, Ai, Chun-Zhi, Sun, Xiao-Yu, Hong, Mo, Ge, Guang-Bo, Gonzalez, Frank J., Ma, Xiao-Chi, Sun, Hong-Zhi
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2013
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826681/
https://ncbi.nlm.nih.gov/pubmed/24115227
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M040519
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