Combination of ERG9 Repression and Enzyme Fusion Technology for Improved Production of Amorphadiene in Saccharomyces cerevisiae

The yeast strain (Saccharomyces cerevisiae) MTCC 3157 was selected for combinatorial biosynthesis of plant sesquiterpene amorpha-4,11-diene. Our main objective was to overproduce amorpha 4-11-diene, which is a key precursor molecule of artemisinin (antimalarial drug) produced naturally in plant Arte...

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Autors principals: Baadhe, Rama Raju, Mekala, Naveen Kumar, Parcha, Sreenivasa Rao, Prameela Devi, Yalavarthy
Format: Artigo
Idioma:Inglês
Publicat: Hindawi Publishing Corporation 2013
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826331/
https://ncbi.nlm.nih.gov/pubmed/24282652
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2013/140469
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