Long term myriocin treatment increases MRP1 transport activity

We investigated the effect of myriocin treatment, which extensively depletes sphingolipids from cells, on multidrug resistance-related protein 1 (MRP1) efflux activity in MRP1 expressing cells and isolated plasma membrane vesicles. Our data reveal that both short term (3 days) and long term (7 days)...

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Autori principali: Meszaros, Peter, Klappe, Karin, van Dam, Annie, Ivanova, Pavlina T., Milne, Stephen B., Myers, David S., Brown, H. Alex, Permentier, Hjalmar, Hoekstra, Dick, Kok, Jan W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3826170/
https://ncbi.nlm.nih.gov/pubmed/23178537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2012.11.009
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