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Elastase and matrix metalloproteinase inhibitors induce regression, and tenascin-C antisense prevents progression, of vascular disease

Increased expression of the glycoprotein tenascin-C (TN) is associated with progression of clinical and experimental pulmonary hypertension. In cultured smooth muscle cells (SMCs) TN is induced by matrix metalloproteinases (MMPs) and amplifies the proliferative response to growth factors. Conversely...

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Bibliografische gegevens
Hoofdauteurs: Cowan, Kyle Northcote, Jones, Peter Lloyd, Rabinovitch, Marlene
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2000
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC382582/
https://ncbi.nlm.nih.gov/pubmed/10619858
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