Anti-apoptotic phenotypes of cholestan-3β,5α,6β-triol-resistant human cholangiocytes: characteristics contributing to the genesis of cholangiocarcinoma

The oxysterols cholestan-3β, 5α, 6β-triol (Triol) and 3-keto-cholest-4-ene (3K4) are increased in Opisthorchis viverrini-associated hamster cholangiocarcinoma and induce DNA damage and apoptosis via a mitochondria-dependent mechanism in MMNK-1 human cholangiocytes. Based on these observations, we hy...

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Detalhes bibliográficos
Main Authors: Jusakul, Apinya, Loilome, Watcharin, Namwat, Nisana, Techasen, Anchalee, Kuver, Rahul, Ioannou, George, Savard, Christopher, Haigh, W. Geoffrey, Yongvanit, Puangrat
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825754/
https://ncbi.nlm.nih.gov/pubmed/23959098
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsbmb.2013.08.004
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