Oligopeptides stimulate glucagon-like peptide-1 secretion in mice through proton-coupled uptake and the calcium-sensing receptor

AIMS/HYPOTHESIS: Ingested protein is a well-recognised stimulus for glucagon-like peptide-1 (GLP-1) release from intestinal L cells. This study aimed to characterise the molecular mechanisms employed by L cells to detect oligopeptides. METHODS: GLP-1 secretion from murine primary colonic cultures an...

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Main Authors: Diakogiannaki, Eleftheria, Pais, Ramona, Tolhurst, Gwen, Parker, Helen E., Horscroft, James, Rauscher, Beate, Zietek, Tamara, Daniel, Hannelore, Gribble, Fiona M., Reimann, Frank
Format: Artigo
Language:Inglês
Published: Springer Berlin Heidelberg 2013
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3825574/
https://ncbi.nlm.nih.gov/pubmed/24045836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00125-013-3037-3
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