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Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes
A sigma-2 receptor agonist siramesine has been shown to trigger cell death of cancer cells and to exhibit a potent anticancer activity in vivo. However, its mechanism of action is still poorly understood. We show that siramesine can induce rapid cell death in a number of cell lines at concentrations...
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| Hlavní autoři: | , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
Nature Publishing Group
2013
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3824671/ https://ncbi.nlm.nih.gov/pubmed/24091661 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2013.361 |
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