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tPA as a therapeutic target in stroke

BACKGROUND: Ischemic stroke is a leading cause of morbidity and mortality worldwide and recombinant human tissue-type Plasminogen Activator (tPA) is the prominent among very few therapeutics used in its treatment. Due to complications attributed to the drug, most notably transformation of ischemia t...

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Bibliographic Details
Main Authors: Gravanis, Iordanis, Tsirka, Stella E.
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3824365/
https://ncbi.nlm.nih.gov/pubmed/18208365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/14728222.12.2.159
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