Normal Hematopoietic Stem Cells within the AML Bone Marrow Have a Distinct and Higher ALDH Activity Level than Co-Existing Leukemic Stem Cells

Persistence of leukemic stem cells (LSC) after chemotherapy is thought to be responsible for relapse and prevents the curative treatment of acute myeloid leukemia (AML) patients. LSC and normal hematopoietic stem cells (HSC) share many characteristics and co-exist in the bone marrow of AML patients....

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Detalhes bibliográficos
Main Authors: Schuurhuis, Gerrit J., Meel, Michael H., Wouters, Floris, Min, Lisa A., Terwijn, Monique, de Jonge, Nick A., Kelder, Angele, Snel, Alexander N., Zweegman, Sonja, Ossenkoppele, Gert J., Smit, Linda
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823975/
https://ncbi.nlm.nih.gov/pubmed/24244383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078897
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