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Downregulation of IFNG in CD4(+) T Cells in Lung Cancer through Hypermethylation: A Possible Mechanism of Tumor-Induced Immunosuppression

Tumor survival is significantly correlated with the immune response of patients. IFNG plays an important role in the tumor host response and decreased IFNG expression is often observed in lung cancer. Studies have shown that CpG island hypermethylation plays a critical role in transcriptional silenc...

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Detalhes bibliográficos
Main Authors: Wang, Fang, Xu, Jian, Zhu, Quan, Qin, Xuejun, Cao, Yan, Lou, Jiangfang, Xu, Yuqiao, Ke, Xing, Li, Qing, Xie, Erfu, Zhang, Lixia, Sun, Ruihong, Chen, Liang, Fang, Bingliang, Pan, Shiyang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823966/
https://ncbi.nlm.nih.gov/pubmed/24244422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079064
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