A Phase 1b Randomized, Controlled, Double-Blinded Dosage-Escalation Trial to Evaluate the Safety, Reactogenicity and Immunogenicity of an Adenovirus Type 35 Based Circumsporozoite Malaria Vaccine in Burkinabe Healthy Adults 18 to 45 Years of Age

BACKGROUND: Ad35.CS.01 is a pre-erythrocytic malaria candidate vaccine. It is a codon optimized nucleotide sequence representing the P. falciparum circumsporozoite (CS) surface antigen inserted in a replication deficient Adenovirus 35 backbone. A Phase 1a trial has been conducted in the USA in naïve...

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Detalhes bibliográficos
Main Authors: Ouédraogo, Alphonse, Tiono, Alfred B., Kargougou, Désiré, Yaro, Jean Baptiste, Ouédraogo, Esperance, Kaboré, Youssouf, Kangoye, David, Bougouma, Edith C., Gansane, Adama, Henri, Noelie, Diarra, Amidou, Sanon, Souleymane, Soulama, Issiaka, Konate, Amadou T., Watson, Nora L., Brown, Valerie, Hendriks, Jenny, Pau, Maria Grazia, Versteege, Isabella, Wiesken, Edison, Sadoff, Jerald, Nebie, Issa, Sirima, Sodiomon B.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823848/
https://ncbi.nlm.nih.gov/pubmed/24244339
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0078679
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