TAP Mediates Import of Mycobacterium tuberculosis-Derived Peptides into Phagosomes and Facilitates Loading onto HLA-I

Processing and presentation of antigen on MHC-I class I molecules serves to present peptides derived from cytosolic proteins to CD8(+) T cells. Infection with bacteria that remain in phagosomal compartments, such as Mycobacterium tuberculosis (Mtb), provides a challenge to this immune recognition as...

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Bibliographic Details
Main Authors: Harriff, Melanie J., Burgdorf, Sven, Kurts, Christian, Wiertz, Emmanuel J. H. J., Lewinsohn, Deborah A., Lewinsohn, David M.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2013
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823705/
https://ncbi.nlm.nih.gov/pubmed/24244525
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079571
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