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Chromosomal instability correlates with poor outcome in patients with myelodysplastic syndromes irrespectively of the cytogenetic risk group

Chromosomal instability (CIN), defined by an elevated frequency of the occurrence of novel chromosomal aberrations, is strongly implicated in the generation of aneuploidy, one of the hallmarks of human cancers. As for aneuploidy itself, the role of CIN in the evolution and progression of malignancy...

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Dettagli Bibliografici
Autori principali: Heilig, Christoph E, Löffler, Harald, Mahlknecht, Ulrich, Janssen, Johannes WG, Ho, Anthony D, Jauch, Anna, Krämer, Alwin
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2010
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3823121/
https://ncbi.nlm.nih.gov/pubmed/19754665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1582-4934.2009.00905.x
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