Polyplex-Microbubble Hybrids for Ultrasound-Guided Plasmid DNA Delivery to Solid Tumors

Microbubble ultrasound contrast agents are being developed as image-guided gene carriers for targeted delivery in vivo. In this study, novel polyplex-microbubbles were synthesized, characterized and evaluated for systemic circulation and tumor transfection. Branched polyethylenimine (PEI; 25 kDa) wa...

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Main Authors: Sirsi, Shashank, Hernandez, Sonia, Zielinski, Lukasz, Blomback, Henning, Koubaa, Adel, Synder, Milo, Homma, Shunichi, Kandel, Jessica J., Yamashiro, Darrell J., Borden, Mark A.
Format: Artigo
Language:Inglês
Published: 2011
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3822338/
https://ncbi.nlm.nih.gov/pubmed/21945680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jconrel.2011.09.071
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