Trastuzumab Alters the Expression of Genes Essential for Cardiac Function and Induces Ultrastructural Changes of Cardiomyocytes in Mice

Treatment with trastuzumab, a humanized monoclonal antibody directed against the extracellular domain of Human Epidermal Growth Factor Receptor 2 (HER2), very successfully improves outcomes for women with HER2-positive breast cancer. However, trastuzumab treatment was recently linked to potentially...

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Hlavní autoři: ElZarrad, M. Khair, Mukhopadhyay, Partha, Mohan, Nishant, Hao, Enkui, Dokmanovic, Milos, Hirsch, Dianne S., Shen, Yi, Pacher, Pal, Wu, Wen Jin
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2013
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821852/
https://ncbi.nlm.nih.gov/pubmed/24255707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0079543
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