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Investigations of the Binding of [Pt(2)(DTBPA)Cl(2)](II) and [Pt(2)(TPXA)Cl(2)](II) to DNA via Various Cross-Linking Modes
We have constructed models for a series of platinum-DNA adducts that represent the binding of two agents, [Pt(2)(DTBPA)Cl(2)](II) and [Pt(2)(TPXA)Cl(2)](II), to DNA via inter- and intra-strand cross-linking, and carried out molecular dynamics simulations and DNA conformational dynamics calculations....
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Molecular Diversity Preservation International (MDPI)
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821573/ https://ncbi.nlm.nih.gov/pubmed/24077126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms141019556 |
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