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Alcohol decreases RhoA activity through a Nitric Oxide (NO)/Cyclic GMP(cGMP)/Protein Kinase G (PKG)-dependent pathway in the airway epithelium

BACKGROUND: Alcohol has been shown to have a number of harmful effects on the lung, including increasing the risk of pneumonia and bronchitis. How alcohol increases the risk of these diseases is poorly defined. RhoA is a small guanosine triphosphate (GTP)ase that plays an integral role in many basic...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Bailey, Kristina L, Robinson, James E, Sisson, Joseph H, Wyatt, Todd A
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3821532/
https://ncbi.nlm.nih.gov/pubmed/21410486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1530-0277.2011.01463.x
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